BPC-157 Research Guide

BPC-157 is a synthetic pentadecapeptide derived from a partial sequence of body protection compound (BPC) isolated from human gastric juice. It consists of 15 amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) and is studied primarily in pre-clinical models of tissue injury and gastrointestinal physiology.

Background

The peptide was first characterized in the 1990s by Sikiric and colleagues at the University of Zagreb. Subsequent rodent studies have examined its activity in models of tendon, ligament, and muscle injury, as well as gastric ulceration. The original designation "Body Protection Compound" reflects this broad pre-clinical interest; clinical evidence in humans remains limited.

Proposed mechanisms (pre-clinical)

• Modulation of the nitric-oxide (NO) system, including interactions with both NOS agonists and antagonists in rodent models.
• Upregulation of growth factor receptors implicated in tissue repair, notably the VEGFR2 pathway in some endothelial preparations.
• Influence on the dopaminergic and serotonergic systems in stress-injury models.

These mechanisms are model-dependent and should not be extrapolated to clinical recommendations.

Storage and handling

Lyophilized BPC-157 is generally stored at ≤ −20°C and protected from light. After reconstitution with bacteriostatic or sterile water, storage at 2–8°C is typical for short-term laboratory use. Repeated freeze-thaw cycles should be avoided.

How Innate Research ships it

Every batch of BPC-157 ships with a third-party Certificate of Analysis confirming identity (mass spectrometry) and purity (HPLC). For background on how to interpret those documents, see our COA education article.

References (representative)

• Sikiric P, et al. Pentadecapeptide BPC 157 and the central nervous system. Neural Regen Res. 2022.
• Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol. 2011.